Abstract
The present study was undertaken to examine the effects of endothelium and exogenous NO on the baroreceptor discharge of the carotid sinus. The baroreceptor activity (BRA) was recorded from the rabbit carotid sinus-sinus nerve (CS-CSN) preparation using a chamber for superfusing and perfusing the tissue. The results are as follows. (1)The CSN hasal discharge could be divided into two components, a low-amplitude component and a high-amplitude one. The high-amplitude discharge was dependent on pulsatory perfusing pressure, but did not respond to classical chemoreceptor stimulants,indicating its baroreceptive origin. (2) The BRA was decreased after removal of the endothelium. (3 ) L-arginine (L-arg), as exogenous NO, initiated BRA in a dosedependent manner, which was prevented by precedent inhibition of NO synthase or by removalof the endothelium. (4) Inhibition of guanine nucleotide cyclase with methylene blue effected neither the hasal BRA nor the response of BRA to L-arg.
Received: Accepted:
Corresponding author: E-mail:
Citing This Article：
, , , . . Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).
Copyright © 1927-2022 Acta Physiologica Sinica All Rights Reserved
Address: Room 405, Building 31B, 319 Yueyang Road, Shanghai 200031, China Tel: +86-21-54922832 E-mail: actaps@sinh.ac.cn
沪ICP备05033115号-81
