Issue Archive

MA Yong-Jie

2College of Information Engineering, Taishan Medical University, Taian 271016, China

Abstract

The extent increase of Ca2+/CaM-dependent protein kinase Ⅱ (CaMK Ⅱ)autophosphorylation in various brain regions of rat reached a maximum value, one hour after s. c. drinistration of AVP(4-8). The increase in the cortex amounted to 192% of the control (P< 0.001 ), whi1e in the hippocampus only 40% (P<0.05). The autophosphorylation of CaMKⅡ was dependent on both Ca2+ and CaM. Western blotting with anti-CaMKⅡa monoclonal antibody showed that the content of CaMK Ⅱ α in cortex did not show detectable change in 1 h as compared to the control group.ZDC(C)PR, an antagonist of AVP(4-8), markedly blocked the effect of AVP(4-8), suggesting that AVP (4-8) stimulated CaMK Ⅱautophosphorylation is mediated through its receptor.

Key words: ;;;;;

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

MA Yong-Jie. . Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).