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MA Yong-Jie

2College of Information Engineering, Taishan Medical University, Taian 271016, China

Abstract

Modulation of bradykinin(BK)on ATP-activated membrane currents in the isolated rat dorsal root ganglion(DRG)neurons was investigated using whole-cell patch-clamp technique.In 56 neurons examined,BK(10-6～1O-4 mol/L)-induced responses were as follow:(1)inward current (40/56);(2) outward current(7/56);(3)no responses(9/56).In the majority of the neurons examined,ATP(l0-6～1O-3 mol/L)astivated a concentration-dependent inward current with obvious desensitization.ATP activated current was potentiated markedly by preapplication of BK.The enhancement of BK was depndent on the concentration of BK and ATP.It was found that BK potentiated the peak value of ATP-activated currents predominately while the steady state value was not affected obviously.The onset of BK potentiation of ATP-activated currents needed preincubation of BK at least for 3O s and the time of the enhancement lasted over 2O min.The results suggest that BK may play a role in the facilitation of the exitatory effect of ATP on primary sensory neurons.

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Citing This Article：

MA Yong-Jie. . Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).