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Li Wenjue

Department of Physiology, Shanghai College of Traditional Chinese Medicine. Shanghai, China

Abstract

Whole-cell patch-clamp recordings were performed on neurons from freshly isolated rat dorsal root ganglion (DRG) to investigate modulatory effects of clonidine,an α2 adrenoceptor agonist,on GABA-activated currents.In the majority of the neurons examined(72/75),GABA(10-6～10-3 mol/L)induced a concentration-dependent inward current,Which could be blocked by bicuculine(10-4～10-5 mol/L).In 51 out of 72 cells,pretreatment with different dosages of clonidine(10-8～10-4 mol/L)decreased the GABA(10-4 mol/L)-activated current by 8.5%,19.0%,33.4%,44.4% and 40.3%,respectively,while clonidine itself only induced a slight inward current in a few cells (12/72).The inhibitory action of clonidine blockable by yohimbine (10-4 mol/L)was voltage-independent and did not change the membrane conductance during the activation of GABAA receptor.Unlike NA,(-)-isoproternol(10-4～10-5 mol/L)exerted no effect on GABA-activated currents.

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Citing This Article：

Li Wenjue. . Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).