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Changes in firing rate of noradrenergic neurons in locus coeruleus following intravenous administration of estradiol in female rats at different stages of the estrous cycle

Zhu Dini, Zhao Jianchu

Research Department of Physiology, Shaanxi Academy of Traditional Chinese Medicine

Abstract

After intravenous administration of estradiol, the firing rate of NE-ergic neurons in the locus coeruleus (LC) was decreased in the estrus female rats, but increased during the diestrus phase or in ovariectomized rats. The spontaneous firing rate of NE-ergic neurons was positively correlated with the discharge of estradiol injection in the diestrus rats.The firing rate of NE-ergic neurons in the ovariectomized female rats was lower than that in the estrus and diestrus female.These results suggest that estradiol might modulate the spontaneous discharge of NE-ergic neurons in LC as reflected by the different effects of such neurons at different stages of the estrous cycle.

Key words: Estradiol;Noradrenergic neuron;Locus coeruleus;Estrus;Diestrus;Rat

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Citing This Article：

Zhu Dini, Zhao Jianchu. Changes in firing rate of noradrenergic neurons in locus coeruleus following intravenous administration of estradiol in female rats at different stages of the estrous cycle. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).