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Effect of tyrosine on nucleic acid synthesis in uterus, ovaries and testes in rats

Lai Muxian, Wang Xianchen, Sun Qinmei

Harbin Medical Uniaersity. Heilongjiang, China

Abstract

It has been reported that tyrosine affects reproductive function. Our results show that tyrosine has a considerably inhibitory effect to the nucleic acid synthesis in the rat uterus, ovaries, testes and liver. Both RNA and DNA contents of the treated organs are significantly lower than the control values. However, tyrosine has no effect on the incorporation of ~(3)H-TdR or ~(3)H-UR into nucleic acids in heart, spleen and kidneys in the rat. This indicates that tyrosine possesses organ specificity to nucleic acid metabolism. The effects of tyrosine, progesterone and actinomycin D on nucleic acid synthesis in the rat uterus and ovaries are also compared, and the results show that all of them have the similar inhibition effects on DNA and RNA synthesis. The experiment suggests that tyrosine probably is one of the factors involved in nucleic acid biosynthesis in some sexual organs in rats.

Key words: Uterus;Ovaries;Testes;Tyrosine;Ribonucleic acid;Deoxyribonucleic acid

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Citing This Article：

Lai Muxian, Wang Xianchen, Sun Qinmei. Effect of tyrosine on nucleic acid synthesis in uterus, ovaries and testes in rats. Acta Physiol Sin 1986; 38 (3): (in Chinese with English abstract).