Issue Archive

Effect of intra-cerebroventricular injection of glucagon on serum total cholesterol and triglyceride in rabbits

Chang Jianfu, Ma Shuxian, Lu Qihua, Guo Yanshi

Department of Physiology, Xu Zhou Medical College. Jiangsu, China；Department of Physiology, Beijing Medical University. Beijing, China

Abstract

We have recently reported that concentration of plasma FFA was markedly decreased in male rabbits after the intro-cerebroventricular infusion of glucagon. In this study the effects of injection of glucagon were investigated in the same site on serum total cholesterol (TC) and triglyceride (TG) in rabbits. The results were as follows: 1. No significant change of serum TC was observed after intro-cerebroventricular administration of glucagon. 2. A dose-dependent decrease in the concentration of serum TG was produced when glucagon was infused intro-cerebroventricularly. The serum TG level reached a minimal value at 75 min after injection, and then returned to normal gradually. 3. The above mentioned effect of glucagon on the serum TG level was not abolished by atropine injected subcutaneusly or propranolol injected intravenously, but abolished by intravenous injection of phentolamine. It is suggested from these results that glucagon in the brain might participate in the regulation of fat metabolism and this action might be produced through the adrenergic #alpha#-receptors.

Key words: Intro-cerebroventricular i. c. v.;Glucagon;Total cholesterol;Triglyceride

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Chang Jianfu, Ma Shuxian, Lu Qihua, Guo Yanshi. Effect of intra-cerebroventricular injection of glucagon on serum total cholesterol and triglyceride in rabbits. Acta Physiol Sin 1986; 38 (3): (in Chinese with English abstract).