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Effects of sodium tanshinone Ⅱ-A sulfonate on slow action potentials of dissociated single ventrlcular cells of adult guinea pig heart

Liu Qiying, Tsai Tidao

Shanghai Institute of Physiology, Chinese Academy of Science

Abstract

The sodium channels of dissociated single ventricular cells of adult guinea
pig heart were inactivated by partial depolarization in high K~(+) (25 mmol/L)
Tyrode's solution and slow response action potential was elicited by intracellular stimulation. An obvious inhibition of the response was observed in the presence of 20#mu#mol/L sodium tanshinone Ⅱ-A sulfonate(DS-201). In the concentration range from 1#mu#mol/L to 20#mu#mol/L, the inhibition effect of sodium tanshinone Ⅱ-A sulfonate on the slow response action potentials enhanced by 0.28#mu#mol/L isoprenaline is concentration-dependent. Moreover, the inhibition effects of sodium tanshinone Ⅱ-A sulfonate become stronger with the increase (In the range of 6.9 nmol/L to 0.55#mu#mol/L) of isoprenaline. The abovementioned results suggest that sodium tanshinone Ⅱ-A sulfonate may be a kind of effective calcium channel blocker.

Key words: Dissociated ventricular myocytes;Slow response action potential;Sodium tanshinone Ⅱ-A sulfonate

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Citing This Article：

Liu Qiying, Tsai Tidao. Effects of sodium tanshinone Ⅱ-A sulfonate on slow action potentials of dissociated single ventrlcular cells of adult guinea pig heart. Acta Physiol Sin 1990; 42 (3): (in Chinese with English abstract).