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Adrenergic receptor antagonist prevents the left ventricle with chronic pressure-overload from electrical remodeling

Wu Bowei

Department of Pharmacology ShanXi Medical University. Taiyuan, Shanxi 030001, China

Abstract

Experiments were performed to investigate the effects of long-term treatment with adrenergic receptor antagonist on electrical remodeling of the left ventricle with chronic pressure-overload. New Zealand rabbits underwent subtotal banding of superrenal abdominal aorta. At 10 weeks after surgery, echocardiography examination was performed, then action potential (AP), inward rectifier potassium current (Ikj), delayed rectifier potassium current (IK) and Na+/Ca2+ exchanger current (INa+/Ca2+) were recorded in midmyocardial cells isolated from left ventricle of abdominal aorta banded group (banded group), abdominal aorta banding plus Carvedilol intervention group (Carvedilol group), and normal control group rabbits by using the whole-cell patch-clamp techniques. The results showed that left ventricular mass index in control, banded, and Carvedilol groups were 1.78±0.06 (n=7), 2.33±0.11 (n=7), and 1.87±0.08 (n=7), respectively (banded vs control and Carvedilol, P＜0.01).

Key words: P0hysiology;Patch-clamp techniques;Carvedilol;Ventricular remodeling;Ionic channel

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Citing This Article：

Wu Bowei. Adrenergic receptor antagonist prevents the left ventricle with chronic pressure-overload from electrical remodeling. Acta Physiol Sin 2004; 56 (4): (in Chinese with English abstract).