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Effects of cholecystokinirr octapeptide on the tension of pd monary artery in rabbits with endotoxic shock

DUAN Guo- Chen, LING Yi- Ling, GU Zheng Yong, WEI Peng, NIU Zhi- Yun, Yang Shifang

Department of Pathophysiology，Hebei Medical University，Shijiazhuang 050017

Abstract

For investigation of the regulatory mechanism of cholecystokinixr octapeptide(CCK 8)on pulmonary circulation in rabbits with endotoxic shock(ES) induced by lipopolysaccharides(LPS)，mean arterial pressure(MAP) and pulmonary arterial pressure(PAP) were evaluated for 5 h in five groups of rabbits:group of LPS(8 mg/ kg，i. v.)一induced ES，group of CCK 8 pretreatment(15 ug/ kg，i. v.)15min before LPS administration(8 mg/ kg，i. v.)，group of proglumide pretreatment(1 mg/ kg，i. v.)15min before LPS administration(8 mg/ kg，i. v.)，group of CCK(15 ug/ kg，i. v.)only，and normal saline(control) group .The pulmonary arterial tension was measured with isolated vascular ring tech-
nique·The results showed that LPS-induced pulmonary arterial hypertension was abolished by CCK 8.In contrast，proglu mide，a nonspecific antagonist of CCK 8 receptor，potentiated the deleterious effect of LPS .The contractile response of isolated pulmonary artery to a adrenoceptor agonist phenylephrine(PE)
was enhanced and the relaxation response to acetylcholine(ACh) was depressed significantly after LPS was injected，but the effect could be reversed by CCK 8·These results suggest that pulmonary circulation is improved by CCK 8 in ES，and the regulatory effects of CCK 8 may be brought about by modulating the pulmonary arterial tension.

Key words: cholecystokinixr octapeptide;Endotoxic shock;Pulmonary artery;vascular tension

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Citing This Article：

DUAN Guo- Chen, LING Yi- Ling, GU Zheng Yong, WEI Peng, NIU Zhi- Yun, Yang Shifang. Effects of cholecystokinirr octapeptide on the tension of pd monary artery in rabbits with endotoxic shock. Acta Physiol Sin 2003; 55 (2): (in Chinese with English abstract).