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ALTERATION OF MONOAMINE CONTENTS IN MICRODIALYSATE FOLLOWING DROPERIDOL ENHANCED ELECTROACUPUNCTURE

ZHU CHONG-BIN, LI XIAO-YAN, ZHU YAN-HUA, WU GEN-CHENG , XU SHAO-FEN

(State Key Laboratory of Medical Nezc'iology, Shanghai Medical liaiversity, Shanghai 200032)

Abstract

The monoamine contents in microdialysate from rat brain before and after droperidol (DRO)，a dopamine (DA) antagonist，enhanced electroacupuneture-induced analgesia (EA) were measured using techniques of in;二。microdialysis and high performance liquid chromatography with electrochemical detection (HPLC-EC)，so as to investigate the monoamine mechanism of the potentiating effect of DRO on acupuncture analgesia (AA).The results showed that the levels of DA and its metabolites homovanillic acid (HVA) in perfusate increased after EA(P<0. 05 or 0. 0l)，and further increased after DRO+EA (P<0. 05 and 0. 0l，vs EA treatment).A significant decrease in norepinephrine (NE) content after EA (P<0. 0l)was observed，but no further change after DRO+EA (P>O. 05，vs EA treatment).The contents of 5-hydroxytryptamine (5-HT) and its metabolite 5一hydroxyindole acetic acid(5一HIAA)we elevated after EA treatment，and a further elevation in 5-HT and 5-HIAA contents induced by DRO +EA was noted. The results in the present study suggest that DRO potentiated AA not
only via antagonizing the activity of dopaminergic system，but also by coordinating the activities of other monoamines in the brain.

Key words: droperidol;Acupuncture analgesia;monoamines;microdialysis

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Citing This Article：

ZHU CHONG-BIN, LI XIAO-YAN, ZHU YAN-HUA, WU GEN-CHENG , XU SHAO-FEN. ALTERATION OF MONOAMINE CONTENTS IN MICRODIALYSATE FOLLOWING DROPERIDOL ENHANCED ELECTROACUPUNCTURE. Acta Physiol Sin 1997; 49 (4): (in Chinese with English abstract).