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ACETYLCHOLINE DECREASES LOW THRESHOLD T-TYPE CALCIUM CONDUCTANCE OF RELAY CELLS IN THE CAT'S LATERAL GENICULATE NUCLEUS

LO Fu-SUN-, S. M. SHERMAN

Shanghm Brain Research Institute, Shanghai 200031

Abstract

The effect of acetylcholine (ACh) on the low threshold T-type Cal-- conductance of relay cells in the cat lateral geniculate nucleus (LGN) was studied using in vitre thalamic slices. Results from both current-clamp and voltage-clamp experiments showed that the low threshold Ca2+ conductance was inhibited by ACh in most (82%)of the LGN neurons tested，even when the membrane potential was clamped to the control level.This inhibitory effect was independent of the changes in membrane potential by ACh.Therefore，ACh might exert a direct action on low threshold Call channels.

Key words: lateral geniculate nucleus;ion channels; T-type calcium conductance;acetylcholine voltage-clamp ;

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Citing This Article：

LO Fu-SUN-, S. M. SHERMAN. ACETYLCHOLINE DECREASES LOW THRESHOLD T-TYPE CALCIUM CONDUCTANCE OF RELAY CELLS IN THE CAT'S LATERAL GENICULATE NUCLEUS. Acta Physiol Sin 1997; 49 (2): (in Chinese with English abstract).