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PARTICIPATE OF NITRIC OXIDE PARTICIPATE IN HYPOXIC REGULATION OF CEREBROVASCULAR TENSION

GU ZHENG-ZHONG, MEI XIAO-JUN, ZHONG KAI-SHENG , LU MING

Shanghai Institute of Physiology, Chines Academy of Science, Shanghai 200031)

Abstract

Making use of nitric oxide synthesase (NOS) inhibitor N'0-nitric-oxide-L-arginine (L-NNA)，the effect of NO and the pressence of endothelial cell on hypoxia-induced vascular dilatation was studied with new-born calve basilar artery. The experimental results show that L-NNA can attenuate the hypoxia-induced vascular dilatation，but the magnitude of attenuation is smaller than that of constriction caused by L-NNA Qn normoxic calve basilar artery. Under hypoxia，the vascular dilatation of endothelial cell denuded artery is smaller than that of endothelial cell intact artery;the difference between them is approximate by the same as the change caused by L-NNA on endothelial
call intact artery. After destroying the endothelial cell，L-NNA has no obvious effect on the vascular tension. These results suggest that NO and endothelial cell are involved in hypoxia-induced vascular dilaxation.

Key words: hypoxia;Cerebral vessels;nitric oxide;endothelial cell

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Citing This Article：

GU ZHENG-ZHONG, MEI XIAO-JUN, ZHONG KAI-SHENG , LU MING. PARTICIPATE OF NITRIC OXIDE PARTICIPATE IN HYPOXIC REGULATION OF CEREBROVASCULAR TENSION. Acta Physiol Sin 1996; 48 (3): (in Chinese with English abstract).