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ROLE OF CARDIAC RENIN-ANGIOTENSIN SYSTEM IN SWIMMING INDUCED PHYSIOLOGICAL MYOCARDIAL HYPERTROPHY

Tian Bin, Gao Guangdao, Liujian, Cao Zhiping, Luxing

(Department of Pathophysudogy, Xian Medical University, Xian 71006’Institute of Vascular Medicine, The Third School of Clinical Medicine, Beijing Medical University, Beijing 100081)

Abstract

To determine the contribution of cardiac renin-angiotensin system (RAS) to the physiological myocardial hypertrophy induced by swimming training and the relationship between locally produced and circulating RAS，both ventricular and plasma angiotensin(Ang)I and I contents，ventricular angiotensin converting enzyme (ACE) and plasma renin activity (PRA) were detected by means of radioimmunoassay and biochemical method. It was shown that after 5 weeks of swimming，the ventricular wet weight to body weight ratio (V /Bwt) and Ang I in both left and right ventricles and ACE activity increased markedly as compared with the controls (PLO. 05). Furthermore，significantly possitive correlation was found between the ventricular Ang I and V /Bwt(:=0. 7721，PGO. 001)，while the plasma Ang I and I and PRA remained at the control level. No correlation was found between plasma Ang I and V /
Bwt. These above findings suggest that cardiac RAS may play an important role in physiological myocardial hypertrophy and to a large extent is in dependent on circulating RAS.

Key words: myocardial hypertrohy;angiotnesin lI;renin

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Citing This Article：

Tian Bin, Gao Guangdao, Liujian, Cao Zhiping, Luxing. ROLE OF CARDIAC RENIN-ANGIOTENSIN SYSTEM IN SWIMMING INDUCED PHYSIOLOGICAL MYOCARDIAL HYPERTROPHY. Acta Physiol Sin 1994; 46 (5): (in Chinese with English abstract).