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ON THE CENTRAL INHIBITION ACTION OF TETRAHYDROBERBERINE WITHOUT RELEVANCE TO GABA RECEPTORS

Wang Xiaoli, Jing Guozhang, Zhou Tingchong

Shanghai Institute of Materia Medical Academy of Science 200031；Institute of Basic Medical Science Academy of Military Science Beijing 100850

Abstract

Using an earthworm (Eisenia foetida) dorsal muscle preparatioO}，it was shown that tetrahydroberberine (THB，10~(7)一10~(4) mol/L) did not affect both GABA and ACh receptors. DA receptor antagonist haloperidol (HAL) also exerted no effect. Owing to the blocking action of isonicotinyl hydrazine(INH)and thiosemicarbazide (TSC) on biosynthesis of GABA，and of picrotoxin (PT) and bicuculline (Bic) on the GABA-BZ receptor complex mediated transmission，all these agents could induce convulsion in mice. This action could be antagonized by amino- oxyacetic acid (AOAA)and benzodiazepine (8Z)，but not by DA receptor antagonists THB and HAL. All the above observations indicate that the GABA inhibition is not involved in the central action of THB.

Key words: tetrahydroberberine;earthworm dorsal muscle;;;

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Citing This Article：

Wang Xiaoli, Jing Guozhang, Zhou Tingchong. ON THE CENTRAL INHIBITION ACTION OF TETRAHYDROBERBERINE WITHOUT RELEVANCE TO GABA RECEPTORS . Acta Physiol Sin 1994; 46 (5): (in Chinese with English abstract).