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Changes in antioxidant capacity of the guinea pig exposed to noise and the protective effect of #alpha#-lipoic acid against acoustic trauma

Diao Mingfang, Liu Haiying, Zhang Yanmin, Gao Wenyuan

Department of Physiology,Second Military Medical University.Shanghai 200433

Abstract

The threshold of hearing in the control group was relatively stable, while the hearing threshold in the noise+saline group was significantly higher than those in the noise+#alpha#-lipoic acid group (P<0.05). TAC level of the noise+saline group was significantly lower than that of the control group (P<0.05). TAC level of the noise+#alpha#-lipoic acid group was significantly higher than that of the noise+saline group (P<0.05), while there was no significant difference in the levels between the noise+#alpha#-lipoic acid group and the control group (P>0.05). The NO level of the cochlear tissue in the noise+#alpha#-lipoic acid group was significantly higher than that of the group (P<0.05), Cochlear NO level in the noise+#alpha#-lipoic acid group was significantly lower than that of the noise+saline group (P<0.05), while there was no significant difference in cochlear NO levels between the noise+#alpha#-lipoic acid group and the control group (P>0.05). The results obtained indicate that noise exposure causes a decrease in serum TAC and on increase in NO in cochlea. #alpha#-Lipoid acid exerts a protective effect against hearing loss in acoustic trauma through its antioxidant effects.

Key words: Noise-induced hearing loss;Cochlea;Total antioxidant capacity;Nitric oxide;#alpha#-lipoic acid

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Citing This Article：

Diao Mingfang, Liu Haiying, Zhang Yanmin, Gao Wenyuan. Changes in antioxidant capacity of the guinea pig exposed to noise and the protective effect of #alpha#-lipoic acid against acoustic trauma. Acta Physiol Sin 2003; 55 (6): (in Chinese with English abstract).