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Effects of AlCl_(3) on transient outward K~(+) current and delayed rectifier K~(+) current in actuely isolated rat hippocampal CA1 neurons

Meng Ziqiang, Bai Wei

Department of Environmental Science and Toxicology,Shanxi University.Taiyuan 030006,Shanxi

Abstract

The effects of aluminum chloride (AlCl_(3)) on the transient outward potassium and delayed rectifier K~(+) current in hippocampal CA1 neurons of rats were studied by the whole--cell patch clamp technique. It was found that AlCl_(3) reduced the transient outward potassium current and delayed rectifer K~(+) current in a dose-dependent manner. 1000 #mu#mol/L AlCl_(3) resulted in change in voltage and slope of the half-activation and the half-inactivation of I_(A) and I_(K). These results imply that AlCl_(3) may damage potassium channel of the hippocampal CA1 neurons from rats and this may be related to the mechanism of the damage to the central nervous system by aluminum.

Key words: Aluminum chloride;Hippocampus;Neurons patch clamp techniques;Potassium channel;

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Citing This Article：

Meng Ziqiang, Bai Wei. Effects of AlCl_(3) on transient outward K~(+) current and delayed rectifier K~(+) current in actuely isolated rat hippocampal CA1 neurons. Acta Physiol Sin 2003; 55 (4): (in Chinese with English abstract).