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Effect of intracarotid administration of adrenomedullin on the spontaneous electrical activity of area postrema neurons in sino-aortic denervated rats

Ji Shumei, Yue Hua, He Ruirong

Department of Physiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

Following intracarotid administration of AM (0.3 nmol/kg), the discharge rate of 47 out of 78 units increased markedly from 2.99±0.24 to 4.79±0.29 spikes/s (P<0.001), 20 units decreased from 3.24±0.46 to 1.97±0.37 spikes/s (P<0.001), and the remaining 11 showed no response. Blood pressure (BP) and heart rate (HR) did not change throughout the experimentation. Pretreatment with intracarotid administration of calcitonin gene-related peptide receptor antagonist CGRP_(8-37) (3 nmol/kg) did not change the effects of AM. Followig intracarotid injection of NO precursor L-arginine (30 mg/kg), the excitatory effect of AM was attenuated. The above results indicate that AM can excite spontaneous electrical activity of AP neurons, this effect is not mediated by calcitonin gene-related peptide receptor but may be attenuated by No precursor L-arginine.

Key words: Adrenomedullin;Area postrema;Spontaneous single-units discharge;Caicitonin gene-related peptide receptor antagonist;L-arginine

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Citing This Article：

Ji Shumei, Yue Hua, He Ruirong. Effect of intracarotid administration of adrenomedullin on the spontaneous electrical activity of area postrema neurons in sino-aortic denervated rats. Acta Physiol Sin 2003; 55 (4): (in Chinese with English abstract).