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Hypoxic preconditioning enhances hypoxic tolerance of hippocampal neurons and synaptic function of rat

Zhao Tong, Yu Shun, Ding Aishi, Wang Fuzhuang, Fan Ming

Department of Neurobiology,Institute of Basic Medical Sciences.Beijing 100850

Abstract

Hypoxic preconditioning with different simulated altitudes (3 000 m and 5 000 m) was performed on Wistar rats and the evoked population spikes were recorded from the hippocampal slices of these rats. The results showed that the appearance of hypoxic injury potential (HIP) and the disappearance of presynaptic volley (PV) were significantly delayed in response to acute lethal hypoxia. HIP and PV delay became more apparent when the hypoxic preconditioning altitude was increased from 3 000 m to 5 000 m. After reoxygenation, the recovery rate of PV in hypoxic preconditioning groups at 3 000 m and 5 000 m was apparently higher than that of control. The above results suggest that hypoxic preconditioning of animals in vivo increases hypoxic tolerance of hippocampal neurons.

Key words: hypoxic preconditioning;evoked population spikes;Hippocampus;hypoxic tolerance

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Citing This Article：

Zhao Tong, Yu Shun, Ding Aishi, Wang Fuzhuang, Fan Ming. Hypoxic preconditioning enhances hypoxic tolerance of hippocampal neurons and synaptic function of rat. Acta Physiol Sin 2001; 53 (1): (in Chinese with English abstract).