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The role of theophylline in the improvement of scop-induced learning and memory impairment

Jin Zonglian, Wen Jing, Wang Weiping, He Wentao

College of Applied Sciences and Humanities of Beijing Union University.Beijing 100083

Abstract

Adenosine and ACh contents in hippocampus, striatum region around the nucleus of basal meynert (NBM) and the frontal and temporal parts of rat cortex were measured by a high performance liquid chromotography-electronic detector (HPLC-ECD). Adenosine content in 180020 month-old rats was significantly higher than that of 3-6 month-old rats, while ACh content in 18-20 month-old rats was lower than that of 3-6 month-old ones. Learning and memory impairment models were established by induction of SD rats with scopolamine (0.5 mg/kg, ip), which were injected with an adenosine recepter antagonist theophylline (1.0 mg/5 #mu#l, icv), and the step-down test was performed.

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Citing This Article：

Jin Zonglian, Wen Jing, Wang Weiping, He Wentao. The role of theophylline in the improvement of scop-induced learning and memory impairment. Acta Physiol Sin 2000; 52 (5): 390-394 (in Chinese with English abstract).