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Effects of microinjection of adenosine into area postrema on heart rate, blood pressure and renal sympathetic nerve activity in rats

Chen Shuang, Li Depei, He Ruirong

Department of Physiology,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

Following microinjection of Ado (1 ng/60 nl) into AP, MAP, HR and RSNA were decreased from 13.76±0.46 kPa, 356.28±4.25 bpm and 100±0% to 11.23±0.49 kPa (P<0.001), 336.91±5.23 bpm (P<0.01) and 70.95±5.19% (P<0.001), respectively; 8-phenyltheophylline (150 #mu#g/kg, 0.2 ml, iv), a nonselective adenosine receptor antagonist, and 8-cyclopentyl-1, 3-dipropylxanthine (500 #mu#g/kg, 0.2 ml, iv), a selective A_(1) adenosine receptor antagonist, blocked the inhibitory effect of Ado completely; and glibenclamide (5 mg/kg, 0.2 ml, iv), a blocker of ATP-sensitive potassium channel, also abolished the effect of Ado.

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Citing This Article:

Chen Shuang, Li Depei, He Ruirong. Effects of microinjection of adenosine into area postrema on heart rate, blood pressure and renal sympathetic nerve activity in rats. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).