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Alteration of sensitivity of supraoptic nucleus neurons to cytokine in the hypothalamic slices from the rat after lipopolysaccharide injection

Wang Xiaobin, Hu Sanjue, Ju Gong

Institute of Neuroscience,the Fourth Military Medical University.Xi^an 710032,Shaanxi

Abstract

Using the whole-cell patch-clamp technique, the effects of interleukin-1#beta# (IL-1#beta#) and IL-2 on the membrane potential and spontaneous discharges in the supraoptic nucleus (SON) neurons from the rat hypothalamic slices in vitro were examined to determine the changes in sensitivity of supraoptic nucleus neurons to cytokine. The results show that the sensitivity of part of SON neurons from the immuned rat to cytokine IL-2 was altered, suggesting that IL-2 may be involved in modulation of the activity of SON neurons and thus play a role in modulation of the immune response.

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Citing This Article：

Wang Xiaobin, Hu Sanjue, Ju Gong. Alteration of sensitivity of supraoptic nucleus neurons to cytokine in the hypothalamic slices from the rat after lipopolysaccharide injection. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).