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Adenosine inhibits spontaneous and glutamate-induced discharges of hippocampal CA1 neurons

Wang Hong, Wang Zhian, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

Effects of adenosine (Ado) on spontaneous and glutamate-induced discharges of neurons in CA1 area of hippocampal slices were examined using extracellular recording technique. The results are suggested that Ado can bind with adenosine A1-receptors on CA1 neurons, resulting in an activation of K_(ATP) channels and inhibition of neuronal activity. The inhibitory effect of Ado on glutamate-induced epileptiform activities in rat hippocampal neurons is also mediated by adenosine A1-receptor with involvement of ATP-sensitive potassium channels.

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Citing This Article：

Wang Hong, Wang Zhian, He Ruirong. Adenosine inhibits spontaneous and glutamate-induced discharges of hippocampal CA1 neurons. Acta Physiol Sin 2000; 52 (4): (in Chinese with English abstract).