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A comparison of calcitonin gene-related peptide effects on coronary flow and cardiac conduction system in the guinea pig

Niu Weizhen, Gao Yanli, Liu Ping, Liu Beiying, Ye Gang

Department of Cardiovascular Physiology,Capital University of Medical Sciences.Beijing 100054

Abstract

The coronary flow (CF) was measured and the right atrium was paced at incremental frequencies periodically. Perfusing heart with CGRP at the concentrations of 3-30 nmol/L inicreased CF strikingly and dose-dependently. CGRP (30 nmol/L) caused a moderate and significant increase in the spontaneous heart rate, but failed to influence the atrioventricular nodal and His bundle-Purkinje fiber conduction time and the longest atrial pacing cycle length inducing 3:2 Wenckebach and 2:1 AV nodal conduction.

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Citing This Article：

Niu Weizhen, Gao Yanli, Liu Ping, Liu Beiying, Ye Gang. A comparison of calcitonin gene-related peptide effects on coronary flow and cardiac conduction system in the guinea pig. Acta Physiol Sin 2000; 52 (3): (in Chinese with English abstract).