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Correlation between the age-related memory impairment and the level of free Ca~(2+) in brain synaptosomes

Zhang Zigui, Xu Xiaohong, Du Hongyan, Wu Fumei

Department of Biology,Zhejiang Normal University.Jinhua 321004,Zhejiang；China

Abstract

In this study, we investigated the changes in the ability of learning-memory of 12-month- and 18-month-old mice, and the intrasynaptosomal Ca~(2+) levels of some mouse brain areas (hippocampus, cerebal cortex, corpus quadrigemi and cerebellum) on the basis of our last behavior observation and biochemistry detection. Meanwhile, the intrasynaptosomal Ca~(2+) levels of the four brain areas were compared between the mice of impaired and good memory. The main results are as follows. With the increase of age, the ability of learning-memory of mice decreased significantly; and the concentration of the intrasynaptosomal free [Ca~(2+)]_(i) in mouse brain areas (except for cerebral cortex) increased markedly, especially in the memory-impaired mice.

Key words: Age related memory impairment;Brain synaptosome;[Ca 2+ ]_(i);Mice

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Citing This Article：

Zhang Zigui, Xu Xiaohong, Du Hongyan, Wu Fumei. Correlation between the age-related memory impairment and the level of free Ca~(2+) in brain synaptosomes. Acta Physiol Sin 2000; 52 (1): (in Chinese with English abstract).