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Effects of intermittent hypoxia on transient outward current in rat ventricular myocytes

Zhou Jun, Tian Ming, Zhang Yi, Zhou Zhaonian

Shanghai Institute of Physiology,Chinese Academy of Sciences.Shanghai 200031；China

Abstract

To explore the ionic basis of the strengthening effect of intermittent hypoxic adaptation (IHA) on the electric stability of heart, the effects of intermittent hypoxia on the transient outward current (Ito) in rat ventricular myocytes were investigated hy using whole-cell patch-clamp recording techniques. It is speculated that the change in the current density of Ito may be responsible for the different hemodynamic responses of the ventricles to the early stage of hypoxia. The alteration in inactivation may participate in the cardioprotective effect of IHA.

Key words: Intermittent hypoxia;Transient outward current;Patchclamp technique;Adaptation heart

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Citing This Article：

Zhou Jun, Tian Ming, Zhang Yi, Zhou Zhaonian. Effects of intermittent hypoxia on transient outward current in rat ventricular myocytes. Acta Physiol Sin 1999; 51 (2): (in Chinese with English abstract).