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Role of basolateral amygdaloid nuclei in sleep and wakeful state regulation

Zhu Guoqing, Zhong Mingkui, Zhang Jingxing, Zhao Lezhang, Ke Daoping, Wang Min, Shi Lei

Department of Physiology,Anhui Medical University.Hefei 230032,Anhui；China

Abstract

The role of basolateral amygdaloid nuclei (BLN) in sleep and wakeful state (W) was investigated with polysomnography. Electrical lesion of bilateral BLN increased show wave sleep (SWS) and paradoxical sleep (PS), but decreased W. Bilateral injection of kainic acid (KA), which selectively destroyed the soma of neurons, resulted in biphasic effects. At d 1 after KA, insomnia occurred. At d 4, SWS increased while W decreased, but PS did not change. Unilateral injection of NO donor sodium nitroferricyanide (SNP) caused an enhancement of W and a decrease of SWS. Injection of nitric oxide synthase inhibitor N-nitro-L-arginine (L-NNA) led to opposite effects. L-arginine, a precursor of NO, had no direct effect on sleep and W, but blocked the effects of L-NNA.

Key words: Amygdaloid complex;Kainic acid;Nitric oxide;Sleep;Wakeful state

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Citing This Article：

Zhu Guoqing, Zhong Mingkui, Zhang Jingxing, Zhao Lezhang, Ke Daoping, Wang Min, Shi Lei. Role of basolateral amygdaloid nuclei in sleep and wakeful state regulation. Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).