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Zinc modulation of GABA receptors expressed in Xenopus oocytes injected with carp brain Poly(A)~(+) RNA

Abstract

Two types of GABA receptors, GABA_(A) receptors (approximately 85%) and GABA_(C)-like receptors (approximately 15%), were expressed in Xenopus oocytes after injection of Poly(A)~(+) RNA with carp (Carassius carassius) brain. Using voltage-clamp technique and pharmacological methods, the effects of zinc on the two receptors were studied. It was found that zinc modulation of both GABA_(A) and GABA_(C)-like receptors by zinc was inhibitory and reversible with the former being stronger than the latter as indicated by a value of IC_(50) of 48.4±10.1#mu#mol/L against 255.6±21.5#mu#mol/L.

Key words: Zinc;GABA_(A) receptor;GABA_(C) receptor;Carp brain;Xenopus oocyte

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Citing This Article：

. Zinc modulation of GABA receptors expressed in Xenopus oocytes injected with carp brain Poly(A)~(+) RNA. Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).