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Effect of adrenomedullin on mesenteric microvessels and microlymphatics in rat

Fan Gui, Niu Chunyu, Han Min, Zhang Jing, Wei Yingjie, Tang Shaoshu, Tang Jian

Department of Pathophysiology, Zhangjiakou Medical College.Zhangjiakou 075029, Hebei；China

Abstract

The dilatant effect of adrenomedullin (ADM), a novel peptide of 52 amino acids, on the mesenteric microvessels andmicrolymphatics was investigated under microscopic observation. 10~(-6) mol/L ADM could also ameliorate alteration of the hemorheology induced by 10~(-5) mol/L morepinephrine (NE) or 10~(-7) mol/L endothelin (ET). However, this ameliorative response was markedly inhibited in the presence of N-nitro-L-arginine (L-NNA), an inhibitor for production of nitric oxide.

Key words: Adrenomedullin;Norepinephrine;Endothelin;Microvessels;Microlymphhatics;Nitric oxide

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Citing This Article：

Fan Gui, Niu Chunyu, Han Min, Zhang Jing, Wei Yingjie, Tang Shaoshu, Tang Jian. Effect of adrenomedullin on mesenteric microvessels and microlymphatics in rat. Acta Physiol Sin 1997; 49 (1): (in Chinese with English abstract).