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Capsaicin-sensitive afferent neurons and endogenous nitric oxide (NO) mediate the gastric acid secretion and hyperemic responses to intragastric peptone

Yan Changdong, Gu Luo, Chen Ming, Tian Suping, Li Dongsheng

Department of Physiology, Nanjing Medical University. Nanjing 210029, Jiangsu

Abstract

Using hydrogen gas chearance technique to measure gastric mucosal blood flow(GMBF) and a high dose of capsaicin to ablate the capsaicin-sensitive afferent neurons, the role of capsaicin-sensitive neurons in the gastric acid secretion and hyperemic response to intragastric peptone was investigated. These results suggested that capsaicin-sensitive afferent neurons and endogenous NO were involved in the gastric acid secretion and hyperemic response to intragastric peptone and the hyperemic response was mediated by both cholinergic and noncholinergic neurons.

Key words: Capeicin-sensitive afferent neurones;Nitric oxide （NO）;Peptone;;;

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Citing This Article：

Yan Changdong, Gu Luo, Chen Ming, Tian Suping, Li Dongsheng. Capsaicin-sensitive afferent neurons and endogenous nitric oxide (NO) mediate the gastric acid secretion and hyperemic responses to intragastric peptone. Acta Physiol Sin 1996; 48 (1): (in Chinese with English abstract).