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Effect of acute hypoxia on blood viscosity, red blood cell deformability and the left ventricular function in rats

Li Xinbo, Guo Xueqin, Liang Zijun

Department of Physiology, Shanghai Medical University. Shanghai 200032；China

Abstract

The left ventricular function and the parameters of hemorrheology during acute hypoxia were investigated. It was found that during acute hypoxia of 15 min, arterial blood gas value PaO_(2) decreased markedly. The parameters of the left ventricular function such as ±dP/dt_(max), Peak, HR, Vce40, Vmp, V_(max), LO(CFU), decreased markedly either. At the same time, hyperviscosity was induced and red blood cell filtration (IF)increased. All these parameters recovered to normal level after reoxgenation of 15 min. By intravenous injection of propranolol (0.5mg/kg) and then hypoxia, the left ventricular function were suppressed markedly; and so were to the elevation of blood viscosity and IF. Preinjection of regitine (3 mg/kg)prior hypoxia has the same effect on the blood viscosity and IF. Acute hypoxia induced hyperviscosity and elevation of IF could be suppressed by destruction of carotid sinus region with phenol, but the left ventricular function decreased markedly.

Key words: Acute hypoxia;Blood viscosity;Lleft ventricular function;Red blood cell deformability

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Citing This Article：

Li Xinbo, Guo Xueqin, Liang Zijun. Effect of acute hypoxia on blood viscosity, red blood cell deformability and the left ventricular function in rats. Acta Physiol Sin 1995; 47 (2): (in Chinese with English abstract).