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自噬与缺氧缺血性脑损伤

厉永强, 付苏, 王来, 刘彬, 石贞玉^*, 邓锦波^*

河南大学护理学院神经生物研究所，开封 475004

摘要

自噬是生物体内高度进化保守的生理机制，包括自噬体形成、自噬体与溶酶体结合以及自噬体降解等过程。生理条件下，自噬主要负责清理细胞内衰老的细胞器及长寿命蛋白，对维持细胞及生物体的自稳状态至关重要。同时，自噬也与许多疾病的发生和发展密切相关，但具体的作用与机制尚不十分明确。以脑卒中为代表的缺氧缺血性脑损伤与自噬的关系是近年来的研究热点，关于自噬在其中的作用与机制尚无定论。本文就自噬在缺氧缺血性脑损伤中的激活、发挥的作用及其机制进行综述，旨在为相关领域的研究提供参考。

关键词： 自噬; 缺氧缺血; 氧化应激; 细胞凋亡

分类号：R329

[Autophagy and hypoxic ischemic brain injuries.] [Article in Chinese]

LI Yong-Qiang, FU Su, WANG Lai, LIU Bin, SHI Zhen-Yu^*, DENG Jin-Bo^*

Institute of Neurobiology, Nursing College, Henan University, Kaifeng 475004, China

Abstract

Autophagy is a highly evolutionarily conserved physiological mechanism of organism, including several stages such as autophagosomes formation, the fusion of lysosomes and autophagosomes, and autophagosomes degradation. In physiological conditions, autophagy is responsible for clearing the spoiled organelles and long-lived proteins to maintain the homeostasis of cells and organism. Meanwhile, autophagy is also involved in the formation and development of diseases, but the mechanism has not been confirmed yet. The relationship between autophagy and hypoxic ischemic brain injuries represented by stroke is a research hotpot in recent years, but there is no clear conclusion about autophagy’s role and mechanism in hypoxic ischemic brain injuries. We reviewed the activation, function and mechanism of autophagy in hypoxic ischemic brain injuries, in order to provide some perspectives on these researches.

Key words: autophagy; hypoxia and ischemia; oxidative stress response; apoptosis

收稿日期：2016-11-24　　录用日期：2017-03-14

通讯作者：石贞玉,邓锦波　　E-mail: henu_szy@foxmail.com, jinbo_deng@henu.edu.cn

引用本文：

厉永强, 付苏, 王来, 刘彬, 石贞玉, 邓锦波. 自噬与缺氧缺血性脑损伤[J]. 生理学报 2017; 69 (3): 316-324.

LI Yong-Qiang, FU Su, WANG Lai, LIU Bin, SHI Zhen-Yu, DENG Jin-Bo. [Autophagy and hypoxic ischemic brain injuries.] [Article in Chinese]. Acta Physiol Sin 2017; 69 (3): 316-324 (in Chinese with English abstract).