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延髓中线区在躯体传入冲动抑制刺激兔下丘脑诱发室性期前收缩中的作用

夏萤, 郭学勤, 李鹏

上海第一医学院生理学教研室. 上海；上海第一医学院基础医学研究所针刺原理研究室. 上海

摘要

于兔延髓中线区闩部头端处微量注射5-HT 受体阻断剂肉桂硫胺(4μg溶于2μl中)可减弱躯体传入冲动对刺激下丘脑诱发的室性期前收缩(HVE)的抑制效应;微量注入阿片受体阻断剂纳洛酮(4μg溶于2μl中)则可完全消除此抑制效应。损毁延髓中线区后,中脑中央灰质微量注入5-HT 或吗啡均不再能抑制 HVE。上述现象提示,躯体传人冲动抑制 HVE 的效应依赖于延髓中线区内啡肽和5-HT 的活动,中脑中央灰质内5-HT 和内啡肽对 HVE 的抑制作用也可能主要是通过延髓中线区的活动而实现。文中还就躯体传入冲动抑制 HVE 的中枢机制进行了讨论。

关键词： 中脑中央灰质; 肉桂硫胺; 下丘脑; 延髓中线区; 纳洛酮; 躯体传入神经刺激; 室性期前收缩

Role of the medial medulla in the inhibitory effect of somatic afferent nerve stimulation on ventricular extrasystoles induced by hypothalamic stimulation in the rabbit

Xia Ying, Guo Xueqin, Li Peng

Department of Physiology, Shanghai First Medical College. Shanghai, China

Abstract

Microinjection of cinanserine (4 #mu#g in 2 #mu#l) into the medial mudulla attenuated the inhibitory effect of somatic afferent nerve stimulation on the hypothalamic stimulation-induced ventricular extrasystoles (HVEs), while microinjection of naloxone (4 #mu#g in 2 #mu#l) into the same area completely blocked the inhibitory effect. The number of HVEs was reduced following microinjection of either 5-HT or morphine into the central gray matter. This effect of 5-HT or morphine microinjection was abolished after destroying the medial portion of the medulla. These results suggest that the inhibitory effect of somatic afferent nerve stimulation on HVEs is mediated by activation of opiate and serotonin receptors in the medial medulla. The neural mechanism of the inhibitory effect of somatic afferent stimulation on HVEs is discussed.

Key words: Central gray matter;Cinanserine;Hypothalamus;Midline region of the medulla;Naloxone;Somatic afferent nerve stimulation;Ventricular extrasystole

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引用本文：

夏萤, 郭学勤, 李鹏. 延髓中线区在躯体传入冲动抑制刺激兔下丘脑诱发室性期前收缩中的作用[J]. 生理学报 1985; 37 (1): .

Xia Ying, Guo Xueqin, Li Peng. Role of the medial medulla in the inhibitory effect of somatic afferent nerve stimulation on ventricular extrasystoles induced by hypothalamic stimulation in the rabbit. Acta Physiol Sin 1985; 37 (1): (in Chinese with English abstract).