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The role and mechanism of autophagy regulator mTOR in renal ischemia-reperfusion injury

LUO Qian¹, YANG Shu-Han², GONG Xia^3,*

¹College of Chinese Medicine, Chongqing Medical University, Chongqing 400016, China；²First Clinical School, Chongqing Medical University, Chongqing 400016, China；³Department of Human Anatomy, College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China

Abstract

Renal ischemia-reperfusion injury (RIRI) is a major cause of acute kidney injury (AKI) and poor kidney transplantation outcomes. Its pathogenesis is closely related to oxidative stress, autophagy, and endoplasmic reticulum stress, although the specific mechanism is still unclear. The mammalian target of rapamycin (mTOR), as a key regulator of autophagy, plays critical roles at various stages of RIRI through different signaling pathways and contributes to mitigating renal damage. However, the underlying mechanisms require further studies. This review focuses on the role and mechanism of mTOR in RIRI and discusses the potential of mTOR as a therapeutic target.

Key words: mammalian target of rapamycin; renal ischemia-reperfusion injury; autophagy

Received: 　　Accepted:

Corresponding author: 龚霞　　E-mail:

DOI: 10.13294/j.aps.2025.0106

Citing This Article：

LUO Qian, YANG Shu-Han, GONG Xia. The role and mechanism of autophagy regulator mTOR in renal ischemia-reperfusion injury. Acta Physiol Sin 2026; 78 (2): 375-384 (in Chinese with English abstract).