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SOX5: A core transcription factor from development to multi-system disease regulation

HU Guang-Xuan¹, YANG Yang², GUO Jin-Shi³, LI Xiao-Ying³, CHANG Bo⁴, YI Xue-Jie^3,*

¹School of Physical Education, Liaoning Normal University, Dalian 116029, China；²Peking University Health Science Center, Beijing 100083, China；³School of Exercise and Health, Shenyang Sport University, Shenyang 110102, China；⁴School of Sports Science, Zhuhai College of Science and Technology, Zhuhai 519041, China

Abstract

SOX5, as an important member of the SOX transcription factor family, is widely involved in various physiological and pathological processes. SOX5 regulates the expression of key genes involved in cell differentiation, proliferation, and development by interacting with specific DNA sequences through its HMG-box DNA-binding domain. SOX5 plays a critical role in cartilage development; it has a key regulatory effect on neuronal migration and differentiation in the nervous system; and it influences gonad development and spermatogenesis in the reproductive system. In terms of diseases, defects in SOX5 are closely associated with Lamb- Shaffer syndrome, type 2 diabetes, and respiratory system diseases. Furthermore, SOX5 plays a role in cancer progression by modulating various signaling pathways to promote or inhibit the proliferation and migration of different types of cancer cells. This review summarizes the physiological and pathological mechanisms of SOX5 in multiple systems and explores its potential as a therapeutic target for disease treatment.

Key words: SOX5; cartilage development; immune modulation; cancer progression; Lamb-Shaffer syndrome

Received: 　　Accepted:

Corresponding author: 衣雪洁　　E-mail:

DOI: 10.13294/j.aps.2025.0080

Citing This Article：

HU Guang-Xuan, YANG Yang, GUO Jin-Shi, LI Xiao-Ying, CHANG Bo, YI Xue-Jie. SOX5: A core transcription factor from development to multi-system disease regulation. Acta Physiol Sin 2025; 77 (6): 1009-1022 (in Chinese with English abstract).