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Molecular mechanism of transcription factor PU.1 regulating erythroid differentiation and its role in hematological diseases

YANG Zi-Jiang, HU Dan, ZHANG Xiu-Juan^*

Department of Physiology, Guangdong Medical University, Zhanjiang 524023, China

Abstract

Transcription factor PU.1, as a core member of the ETS family, plays a pivotal role in the multi-lineage differentiation of hematopoietic stem cells, particularly in the regulation of erythroid differentiation. PU.1 orchestrates the process of hematopoietic stem cell differentiation towards erythroid cells by modulating the transcription of lineage-determining factors and interacting with other key transcription factors in a fine-tuned manner. PU.1 plays an irreplaceable role in the development and function of red blood cells, with its abnormal expression closely related to the occurrence and progression of various blood diseases, including leukemia, myelodysplastic syndromes, and various types of anemia. This article comprehensively analyzes the functional roles and molecular mechanisms of PU.1 in various stages of erythroid differentiation, as well as its potential roles in related blood diseases. This review not only deepens our understanding of the mechanism by which PU.1 regulates erythroid differentiation, but also provides theoretical grounds for blood disease therapies based on PU.1.

Key words: PU.1; erythroid differentiation; transcription factors; erythropoiesis

Received: 　　Accepted:

Corresponding author: 张秀娟　　E-mail:

DOI: 10.13294/j.aps.2025.0076

Citing This Article：

YANG Zi-Jiang, HU Dan, ZHANG Xiu-Juan. Molecular mechanism of transcription factor PU.1 regulating erythroid differentiation and its role in hematological diseases. Acta Physiol Sin 2025; 77 (5): 855-866 (in Chinese with English abstract).