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Progress on the effects of cancer-related fibroblast induced by Helicobacter pylori infection on gastric epithelial-mesenchymal transition

LI Yi-Lin¹, ZHENG Li-Fei^2,*

¹School of Basic Medical Sciences, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China；²Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

Abstract

Helicobacter pylori (Hp) is a Gram-negative bacterium that colonizes in the gastric mucosa. Hp induces the production of cancer-associated fibroblasts (CAF) in the stomach. The virulence factors of Hp and CAF trigger epithelial-mesenchymal transition (EMT), leading to local inflammation, damage to the gastric mucosa, and the occurrence of chronic gastritis. Here, we summarize the molecular mechanisms of CAF mediated gastric EMT after Hp infection, providing new insights into potential molecular targets and strategies for the future treatment of Hp infection associated gastric cancer.

Key words: Helicobacter pylori; cancer-associated fibroblasts; epithelial-mesenchymal transition; transforming growth factor β; PI3K-AKT

Received: 　　Accepted:

Corresponding author: 郑丽飞　　E-mail:

DOI: 10.13294/j.aps.2024.0056

Citing This Article：

LI Yi-Lin, ZHENG Li-Fei. Progress on the effects of cancer-related fibroblast induced by Helicobacter pylori infection on gastric epithelial-mesenchymal transition. Acta Physiol Sin 2024; 76 (4): 547-560 (in Chinese with English abstract).