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The role and mechanism of multifunctional molecule SLPI in regulating ischemia- reperfusion induced acute kidney injury and repair

CHEN Fei¹, WU Yuan-Yuan², YANG Bin^1,3,*

¹Nantong-Leicester Joint Institute of Kidney Science, Department of Nephrology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China；²Department of Pathology, Medical School of Nantong University, Nantong 226001, China；³Renal Research Group, Cardiovascular Sciences, University of Leicester, University Hospitals of Leicester, Leicester LE1 7RH, UK

Abstract

The secretory leukocyte protease inhibitor (SLPI) is mainly produced by immune cells and various epithelial cells, and is regulated by a variety of cytokines, such as transforming growth factor β1, interleukin 1β and tumor necrosis factor α. In addition to commonly known anti-protease activity, it has been found in recent years that SLPI plays essential roles in anti-apoptosis, regulating cell cycle, cell differentiation and proliferation, and inhibiting inflammatory response. SLPI can also assist the immune system to clear pathogens/damaged cells by enhancing the phagocytic function of phagocytes, so as to ameliorate tissue damage and promote repair. Moreover, recent studies have shown that the change of SLPI level in the serum of patients post cardiovascular surgery has a high diagnostic value in predicting the occurrence of acute kidney injury, suggesting that SLPI is involved in ischemia-reperfusion (IR) induced acute kidney injury. In this review, we summarized the expression, regulation, signaling pathways and associated biological events of SLPI in different organ injury models, and also discussed and evaluated the potential role of SLPI in renoprotection against IR induced acute kidney injury and its potential as a new biomarker.

Key words: secretory leukocyte protease inhibitor; acute kidney injury; ischemia-reperfusion injury; biomarkers

Received: 　　Accepted:

Corresponding author: 杨斌　　E-mail:

DOI: 10.13294/j.aps.2024.0027

Citing This Article：

CHEN Fei, WU Yuan-Yuan, YANG Bin. The role and mechanism of multifunctional molecule SLPI in regulating ischemia- reperfusion induced acute kidney injury and repair. Acta Physiol Sin 2024; 76 (3): 475-486 (in Chinese with English abstract).