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Research progress of chemerin in polycystic ovary syndrome

ZHU Xiao-Juan¹, QIU Hang¹, LIU Sheng-Lan¹, DAI Wei¹, HU Hai-Bo^1,2, HUANG Hao^1,3,2,*

¹National Engineering Research Center for Modernization of Traditional Chinese Medicine - Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China；²Department of Biology, KU Leuven; Leuven 3000, Belgium；³State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau 999078, China

Abstract

As a multifunctional adipokine, chemerin plays a crucial role in various pathophysiological processes through endocrine and paracrine manner. It can bind to three known receptors (ChemR23, GPR1 and CCRL2) and participate in energy metabolism, glucose and lipid metabolism, and inflammation, especially in metabolic diseases. Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases, which seriously affects the normal life of women of childbearing age. Patients with PCOS have significantly increased serum levels of chemerin and high expression of chemerin in their ovaries. More and more studies have shown that chemerin is involved in the occurrence and development of PCOS by affecting obesity, insulin resistance, hyperandrogenism, oxidative stress and inflammatory response. This article mainly reviews the production, subtypes, function and receptors of chemerin protein, summarizes and discusses the research status of chemerin protein in PCOS from the perspectives of metabolism, reproduction and inflammation, and provides theoretical basis and reference for the clinical diagnosis and treatment of PCOS.

Key words: chemerin; polycystic ovary syndrome; pathological mechanism

Received: 　　Accepted:

Corresponding author: 黄浩　　E-mail:

DOI: 10.13294/j.aps.2024.0001

Citing This Article：

ZHU Xiao-Juan, QIU Hang, LIU Sheng-Lan, DAI Wei, HU Hai-Bo, HUANG Hao. Research progress of chemerin in polycystic ovary syndrome. Acta Physiol Sin 2024; 76 (3): 429-437 (in Chinese with English abstract).