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Neurotrophin-associated mechanisms of delayed-onset muscle soreness: research progress and perspective

LIU Yun-Xiao¹, LEI Jing^1,2, YOU Hao-Jun^1,2,*

¹Center for Translational Medicine Research on Sensory-Motor Diseases, Yan’an University, Yan’an 716000, China；²Key Laboratory of Yan’an Sports Rehabilitation Medicine, Yan’an 716000, China

Abstract

Delayed-onset muscle soreness (DOMS) is a common phenomenon that occurs following a sudden increase in exercise intensity or unfamiliar exercise, significantly affecting athletic performance and efficacy in athletes and fitness individuals. DOMS is characterized by allodynia and hyperalgesia, and their mechanisms remain unclear. Recent studies have reported that neurotrophic factors, such as nerve growth factor (NGF) and glial cell derived neurotrophic factor (GDNF), are involved in the development and maintenance of DOMS. This article provides a review of the research progress on the signaling pathways related to the involvement of NGF and GDNF in DOMS, hoping to provide novel insights into the mechanisms underlying allodynia and hyperalgesia in DOMS, as well as potential targeted treatment.

Key words: delayed-onset muscle soreness; nerve growth factor; glial cell derived neurotrophic factor; allodynia; hyperalgesia

Received: 　　Accepted:

Corresponding author: 尤浩军　　E-mail: haojunyou@126.com

DOI: 10.13294/j.aps.2024.0017

Citing This Article：

LIU Yun-Xiao, LEI Jing, YOU Hao-Jun. Neurotrophin-associated mechanisms of delayed-onset muscle soreness: research progress and perspective. Acta Physiol Sin 2024; 76 (2): 301-308 (in Chinese with English abstract).