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Experts’ consensus on mammalian cardiomyocyte regeneration

Chinese Society of Integrative Physiology, Chinese Association for Physiological Sciences¹, Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research, Ministry of Education of China¹, ZENG Chun-Yu², YANG Huang-Tian³, GUAN You-Fei^4,*

¹；²Department of Cardiology, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, China；³Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China；⁴Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China

Abstract

Myocardial infarction (MI) leads to a massive loss of cardiomyocytes, resulting in pathological cardiac remodeling and heart failure. Promoting cardiomyocyte regeneration is crucial for repairing the damaged heart. It is acknowledged that regenerative cardiomyocyte derives from the existing cardiomyocytes. In recent years, advancements in this field have updated our understanding of cardiomyocyte regeneration in many aspects, including intrinsic cell source and microenvironmental characteristics, extrinsic factors, molecular biology mechanisms, and intervention strategies. Here, we report a consensus by an expert committee on the definition, characteristics, evaluation, research methods, regulatory mechanisms, and intervention measures related to mammalian cardiomyocyte regeneration. The aim is to clarify important unresolved issues in this field and to promote myocardial regeneration research and its clinical translation.

Key words: Myocardial infarction; heart failure; cardiac remodeling; cardiac regeneration; cardiomyocyte proliferation

Received: 　　Accepted:

Corresponding author: 管又飞　　E-mail: guanyf@dmu.edu.cn

DOI: 10.13294/j.aps.2024.0015

Citing This Article：

Chinese Society of Integrative Physiology, Chinese Association for Physiological Sciences, Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research, Ministry of Education of China, ZENG Chun-Yu, YANG Huang-Tian, GUAN You-Fei. Experts’ consensus on mammalian cardiomyocyte regeneration. Acta Physiol Sin 2024; 76 (2): 175-214 (in Chinese with English abstract).