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Regulatory mechanisms of mitochondrial dynamics and its emerging role in renal pathophysiology

TAN Zi-Xuan, ZHU Wu-Zheng^*

Laboratory of Animal Nutrition and Human Health, College of Life Science, Hunan Normal University, Changsha 410081, China

Abstract

Mitochondria are dynamically changing organelles that maintain stable mitochondrial morphology, number, and function through constant fusion and division, a process known as mitochondrial dynamics, which is an important mechanism for mitochondrial quality control. Excessive fusion and division of mitochondria can lead to a homeostatic imbalance in mitochondrial dynamics, causing mitochondrial dysfunction, leading to cellular damage, and even death. The physiological functions of the kidney are mainly powered by mitochondria, and homeostatic imbalance in mitochondrial dynamics affects mitochondrial function and is closely related to renal diseases such as acute kidney injury and diabetic nephropathy. This article reviews the regulation of mitochondrial kinetics, how imbalances in mitochondrial kinetic homeostasis affect mitochondrial injury, and the impact of mitochondrial injury on renal pathophysiology, in order to improve understanding and knowledge of the role of mitochondria in renal disease.

Key words: mitochondrial fusion; mitochondrial fission; renal disease

Received: 　　Accepted:

Corresponding author: 朱武政　　E-mail: zhuwuzheng8@163.com

DOI: 10.13294/j.aps.2024.0011

Citing This Article：

TAN Zi-Xuan, ZHU Wu-Zheng. Regulatory mechanisms of mitochondrial dynamics and its emerging role in renal pathophysiology. Acta Physiol Sin 2024; 76 (1): 148-160 (in Chinese with English abstract).