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Exercise regulates bone metabolism via microRNAs

YUAN Yu¹, RAO Lin-Zhen¹, ZHANG Shi-Hua^1,2, XU Yang¹, LI Ting-Ting², ZOU Jun², WENG Xi-Quan^1,*

¹School of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China；²School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China

Abstract

It has been well documented that exercise can improve bone metabolism, promote bone growth and development, and alleviate bone loss. MicroRNAs (miRNAs) are widely involved in the proliferation and differentiation of bone marrow mesenchymal stem cells, osteoblasts, osteoclasts and other bone tissue cells, and regulation of balance between bone formation and bone resorption by targeting osteogenic factors or bone resorption factors. Thus miRNAs play an important role in the regulation of bone metabolism. Recently, regulation of miRNAs are shown to be one of the ways by which exercise or mechanical stress promotes the positive balance of bone metabolism. Exercise induces changes of miRNAs expression in bone tissue and regulates the expression of related osteogenic factors or bone resorption factors, to further strengthen the osteogenic effect of exercise. This review summarizes relevant studies on the mechanism whereby exercise regulates bone metabolism via miRNAs, providing a theoretical basis for osteoporosis prevention and treatment with exercise.

Key words: Exercise; microRNA; mechanical stress; bone formation; bone resorption

Received: 　　Accepted:

Corresponding author: 翁锡全　　E-mail: wengxq@gzsport.edu.cn

Citing This Article：

YUAN Yu, RAO Lin-Zhen, ZHANG Shi-Hua, XU Yang, LI Ting-Ting, ZOU Jun, WENG Xi-Quan. Exercise regulates bone metabolism via microRNAs. Acta Physiol Sin 2023; 75 (3): 429-438 (in Chinese with English abstract).