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The role of inflammation in heart failure with preserved ejection fraction

ZHANG Qi¹, CHEN Yun-Er¹, ZHU Xin-Xin¹, WANG Xia^1,2, QU Ai-Juan^1,3,4,*

¹Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China；²Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China；³Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing 100069, China；⁴Beijing Key Laboratory of Metabolic Disorder-Related Cardiovascular Diseases, Beijing 100069, China

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a type of heart failure characterized by left ventricular diastolic dysfunction with preserved ejection fraction. With the aging of the population and the increasing prevalence of metabolic diseases, such as hypertension, obesity and diabetes, the prevalence of HFpEF is increasing. Compared with heart failure with reduced ejection fraction (HFrEF), conventional anti-heart failure drugs failed to reduce the mortality in HFpEF due to the complex pathophysiological mechanism and multiple comorbidities of HFpEF. It is known that the main changes of cardiac structure of in HFpEF are cardiac hypertrophy, myocardial fibrosis and left ventricular hypertrophy, and HFpEF is commonly associated with obesity, diabetes, hypertension, renal dysfunction and other diseases, but how these comorbidities cause structural and functional damage to the heart is not completely clear. Recent studies have shown that immune inflammatory response plays a vital role in the progression of HFpEF. This review focuses on the latest research progress in the role of inflammation in the process of HFpEF and the potential application of anti-inflammatory therapy in HFpEF, hoping to provide new research ideas and theoretical basis for the clinical prevention and treatment in HFpEF.

Key words: heart failure with preserved ejection fraction; inflammation; left ventricular diastolic dysfunction; endothelial dysfunction

Received: 　　Accepted:

Corresponding author: 曲爱娟　　E-mail: aijuanqu@ccmu.edu.cn

Citing This Article：

ZHANG Qi, CHEN Yun-Er, ZHU Xin-Xin, WANG Xia, QU Ai-Juan. The role of inflammation in heart failure with preserved ejection fraction. Acta Physiol Sin 2023; 75 (3): 390-402 (in Chinese with English abstract).