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IL-27: a novel cytokine mediating immune related diseases 

ZHANG Na¹, YANG Yang^1,2, LIANG Qiu-Yan¹, DIAO Xiao-Rui¹, YI Xue-Jie^1,3, CHANG Bo^1,*

¹School of Sports and Human Sciences, Shenyang Sport University, Shenyang 110115, China；²School of Sports and Human Sciences, Shanghai Sport University, Shanghai 200438, China；³Exercise and Health Research Center, Shenyang Sport University, Shenyang 110115, China

Abstract

Interleukin 27 (IL-27) is a pleiotropic cytokine that is involved in the regulation of the body’s innate and adaptive immunity. Previous studies have shown that IL-27 mediates a variety of inflammatory responses in vivo. With the development of animal models and technical tools, several studies have shown that it is also closely associated with autoimmune diseases and other immune related diseases, and is considered as an important candidate for the treatment of viral disease, autoimmune diseases, tumors and obesity. Therefore, this paper reviews recent progress on the role of IL-27 in acquired immunodeficiency syndrome (AIDS), rheumatoid arthritis, tumors and obesity, with the aim of providing new ideas for the treatment of immune related diseases. 

Key words: IL-27; AIDS; rheumatoid arthritis; tumor; obesity

Received: 　　Accepted:

Corresponding author: 常波　　E-mail: changbo8387@163.com

DOI: 10.13294/j.aps.2023.0020

Citing This Article：

ZHANG Na, YANG Yang, LIANG Qiu-Yan, DIAO Xiao-Rui, YI Xue-Jie, CHANG Bo. IL-27: a novel cytokine mediating immune related diseases . Acta Physiol Sin 2023; 75 (2): 303-315 (in Chinese with English abstract).