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The role of adipose-derived exosomes in the pathological progression of atherosclerosis

LIU Lian, HU Hang, GAN Lu^*

Laboratory of Emergency Medicine/Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu 610041, China

Abstract

Atherosclerosis is a chronic inflammatory disease of vascular walls with a complex etiology. In recent years, the incidence of atherosclerosis continues to increase with obesity and diabetes as major risk factors. As an important metabolic organ in the body, adipose tissue also has a powerful endocrine function. In the case of obesity and diabetes, various cytokines and exosomes derived from adipose tissue mediate organ-organ/cell-cell crosstalk, and are involved in the occurrence and development of various diseases. As an important intercellular communicator, exosomes regulate the pathological process of various cardiovascular diseases and are closely related to atherosclerosis. In this paper, we reviewed the mechanism of adipose-derived exosomes in atherosclerosis with focus on endothelial dysfunction, inflammatory response, lipid metabolism disorder and insulin resistance, hoping to provide reference for the research, diagnosis and treatment of atherosclerosis.

Key words: Atherosclerosis; adipose-derived exosomes; pathogenesis

Received: 　　Accepted:

Corresponding author: 甘露　　E-mail: ganlu@wchscu.cn

DOI: 10.13294/j.aps.2023.0032

Citing This Article：

LIU Lian, HU Hang, GAN Lu. The role of adipose-derived exosomes in the pathological progression of atherosclerosis. Acta Physiol Sin 2023; 75 (2): 241-247 (in Chinese with English abstract).