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Progress in application of adult endogenous neurogenesis in brain injury repair

BAI Tian-Yu¹, MU Jiao¹, HAO Peng², DUAN Hong-Mei², HAO Fei¹, ZHAO Wen², GAO Yu-Dan², WANG Zi-Jue², YANG Zhao-Yang², LI Xiao-Guang^1,2,*

¹Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China；²Department of Neurobiology, Capital Medical University, Beijing 100069, China

Abstract

Persistent neurogenesis exists in the subventricular zone (SVZ) of the ventricles and the subgranular zone (SGZ) of the dentate gyrus of the hippocampus in the adult mammalian brain. Adult endogenous neurogenesis not only plays an important role in the normal brain function, but also has important significance in the repair and treatment of brain injury or brain diseases. This article reviews the process of adult endogenous neurogenesis and its application in the repair of traumatic brain injury (TBI) or ischemic stroke, and discusses the strategies of activating adult endogenous neurogenesis to repair brain injury and its practical significance in promoting functional recovery after brain injury.

Key words: traumatic brain injury; ischemic stroke; adult endogenous neurogenesis; functional recovery

Received: 　　Accepted:

Corresponding author: 李晓光　　E-mail: lxgchina@sina.com

DOI: 10.13294/j.aps.2023.0024

Citing This Article：

BAI Tian-Yu, MU Jiao, HAO Peng, DUAN Hong-Mei, HAO Fei, ZHAO Wen, GAO Yu-Dan, WANG Zi-Jue, YANG Zhao-Yang, LI Xiao-Guang. Progress in application of adult endogenous neurogenesis in brain injury repair. Acta Physiol Sin 2023; 75 (2): 231-240 (in Chinese with English abstract).