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Stimulus and reward information encoded by population neurons in the primate prefrontal cortex and striatum

CHEN Su-Hua¹, PAN Xiao-Chuan^1,*, Masamichi Sakagami²

¹Institute of Cognitive Neurodynamics, East China University of Science and Technology, Shanghai 200237, China；²Brain Science Institute, Tamagawa University, Tokyo 194-8610, Japan

Abstract

It has been reported that single-unit activity in the prefrontal cortex (PFC) and striatum represented visual stimulus and reward information. But how to encode these pieces of information is quite complex from the view of single-neuron activity. Different neurons represented stimulus or reward information in different task epochs with increasing or decreasing their activities relative to their baseline firing rates. The present paper was aimed to study whether population neurons in the two brain areas could stably encode task-relevant parameters in a whole trial period. We recorded single-unit activities in the lateral PFC (LPFC) and striatum while the monkey was performing a stimulus- reward prediction task, and analyzed the neuronal activities by the method of a multi-variable regression model and the linear support vector machine. The results showed that, although proportions of task-related neurons in the two areas varied largely in the whole trial period, LPFC population neurons encoded reward and stimulus information stably and reliably. Population neurons in the striatum encoded only reward information, not stimulus information. A group of neurons in the two areas represented combined information of stimulus and reward. Further analysis showed that LPFC neurons encoded reward information for a group of relevant stimuli, while striatal neurons encoded reward information for a specific stimulus. These results suggest that both LPFC and striatal population neurons are able to stably represent task-relevant information, but from different aspects of the task. The different strategies to encode information in the LPFC and striatum suggest their different contributions in reward-based decision making.

Key words: Prefrontal cortex; striatum; reward prediction; population neurons; support vector machine

Received: 2019-11-11　　Accepted: 2020-02-28

Corresponding author: 潘晓川　　E-mail: pxc@ecust.edu.cn

DOI: 10.13294/j.aps.2020.0084

Citing This Article：

CHEN Su-Hua, PAN Xiao-Chuan, Masamichi Sakagami. Stimulus and reward information encoded by population neurons in the primate prefrontal cortex and striatum. Acta Physiol Sin 2020; 72 (6): 765-776 (in Chinese with English abstract).