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Advances on the role of primary cilia in neurological diseases

YANG Xiao-Yu¹, CAO Hong^1,2,*

¹Institutes of Brain Science, Fudan University, Shanghai 200032, China；²Institute of Acupuncture and Moxibustion, Institutes of Integrative Medicine, Fudan University, Shanghai 200032, China

Abstract

Primary cilium, widely distributed in mammalian central nervous system, is an important extracellular organelle of cells.The primary cilia contain a variety of ion channels, G-protein coupled receptors and different kinds of kinases, which indicates thatprimary cilia can detect extracellular signals and transduce them into cells to regulate various cellular and physiological processes. Inhumans, mutations of genes related to structure and function of primary cilia always cause various monogenetic diseases. Moreover, aseries of neuropsychiatric diseases and neurodevelopmental dysplasia are caused by abnormal functions of G-protein coupled receptors,kinases and ion channels in primary cilia. This article reviews recent research progress on the role of primary cilia in related neurological diseases.

Key words: primary cilia; G-protein coupled receptors; type 3 adenylyl cyclase; depression

Received: 2019-07-18　　Accepted: 2019-12-16

Corresponding author: 曹红　　E-mail: hongcao@fudan.edu.cn

DOI: 10.13294/j.aps.2020.0019

Citing This Article：

YANG Xiao-Yu, CAO Hong. Advances on the role of primary cilia in neurological diseases. Acta Physiol Sin 2020; 72 (4): 488-498 (in Chinese with English abstract).