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Caveolin-1: oxidative stress target in tumor cells 

WANG Wen-Hui^1,1, LI Hong-Yan^1,1, QU Chao^1,1, ZHANG Ye-Jun^1,1, ZOU Wei^1,1,*

¹College of Life Sciences, Liaoning Normal University, Dalian 116081, China

Abstract

Aberrant oxidative metabolism in cells is one of the hallmarks of cancer. Overproduction of reactive species promotes carcinogenesis by inducing genetic mutations and activating oncogenic pathways, and thus, antioxidant therapy is considered as an

important strategy for cancer prevention and treatment. Caveolin-1 (Cav-1), a constituent protein of caveolae, is involved in not only the formation of the caveolae, vesicular transport, maintaining cholesterol homeostasis directly, but also many cellular physiological and pathological processes including growth, regulation of mitochondrial antioxidant level, apoptosis and carcinomas by interacting with a lot of signaling molecules through caveolin scaffolding domain. Cav-1 has also been shown to mediate tumor genesis and progression through oxidative stress modulation, while Cav-1-targeted treatment could scavenge the reactive species. Intracellular reactive species could modulate the expression, degradation, post-translational modifications and membrane trafficking of Cav-1. More importantly, emerging evidence has indicated that multiple antioxidants could exert antitumor activities in cancer cells by modulating the signaling of Cav-1. This paper reviewed the research progresses on the roles of Cav-1 and oxidative stress in tumorigenesis and development, and would provide new insights on designing strategies for cancer prevention or treatment.

Key words: caveolin-1; oxidative stress; tumor

Received: 2019-01-16　　Accepted: 2019-03-25

Corresponding author: 邹伟　　E-mail: weizou60@126.com

DOI: 10.13294/j.aps.2019.0047

Citing This Article：

WANG Wen-Hui, LI Hong-Yan, QU Chao, ZHANG Ye-Jun, ZOU Wei. Caveolin-1: oxidative stress target in tumor cells . Acta Physiol Sin 2019; 71 (5): 792-798 (in Chinese with English abstract).